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| S.N. | Characteristics | Serum | Plasma |
| 1. | Definition | Serum is the liquid part of the blood after the coagulation. | Plasma is a clear and yellowish fluid part of the blood. |
| 2. | Composition | Serum is the water fluid from blood without the clotting factors. | Plasma is the blood fluid that contains blood clotting agents. |
| 3. | Volume | Volume of serum is less in comparison to plasma. | Plasma is a clear yellow liquid which is 55% of total volume of blood. |
| 4. | Isolation | Serum is acquired from the process of spinning after clotting. | Plasma is acquired from the process of spinning before clotting. |
| 5. | Isolation Procedure | Serum is more difficult and time consuming to separate. | Plasma is easier and less time consuming to separate as compared with serum. |
| 6. | Use of Anticoagulants | Serum does not need anticoagulants for separation. | Anticoagulants are necessary to separate plasma. |
| 7. | Composition | Serum contains proteins, electrolytes, antibodies, antigens and hormones. | Plasma is considered as the medium of blood in which RBCs (Red Blood Cells), WBC (White Blood Cells) and other components of blood are suspended. |
| 8. | Composition (Antibodies) | Serum contain antibodies and cross react with recipient antigen. | Blood plasma contains antibodies, a type of protein that can fight a substance considered foreign to the host body. |
| 9. | Composition | Serum contains proteins like albumin and globulins. | Plasma contains the clotting factors and water. |
| 10. | Fibrinogen | Absent | Present |
| 11. | Composition (Water) | Serum contains 90% water. | Plasma contains 92-95% water. |
| 12. | Storage | Serum can be stored at 2-6 degrees centigrade for several days. | Frozen plasma can be stored for up to a year. |
| 13. | Density | Serum has a density of approximately 1.024 g/ml. | Plasma has a density of approximately 1025 kg/m3, or 1.025 g/ml. |
| 14. | Arrangement | Cells are usually attached together by clot formation. | Cells are not attached together and suspended in plasma. |
| 15. | Uses | Serum is the most preferred part of blood used in checking blood groups. | Plasma is delivered to the patients who lack blood cells. |
| 16. | Uses | Serum is an important source of electrolytes and animal sera are used as anti-venom, anti-toxins, and vaccinations. | Plasma contains proteins that help in the transportation of material such as glucose and other dissolved nutrients through the blood. |
| 17. | Uses | Serum is used for various diagnostic tests used for determining the levels of hCG, cholesterol, proteins, sugar, etc., in the blood. | Plasma aids in the maintenance of blood pressure and in the regulation of body temperature |